Problems of Radiation Medicine and Radiobiology

Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress

N. К. Rоdionova¹, N. P. Аtаmaniuk¹, L. P. Dеrev’yanko¹, V. V. Tal’ko¹, A. M. Yanina¹,
M. V. Shelkovskiy¹, G. V. Kosyakova², O. Ph. Mehed’², A. G. Berdyshev², N. M. Gula²,
А. А. Chumak1
¹State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
²A.V. Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Leontovych str., 9a, Kyiv, 01601, Ukraine

Objective – to investigate the peculiarities of peripheral blood indices changes in rats under the N-stearoiletanolamine treatment before and after combined effects of ionizing radiation and stress.
Methods: hematological, statistical.
Results: Per oral administration of NSE (10,0 mg / kg) before and after the combined effects of single whole-body irradiation (6.0 Gy) and emotionally-algesic stress (foot-shock) leads to reduction in the number of circulating peripheral blood cells, increasing signs of damage of the hematopoietic system with accelerated exhaustion processes.
Conclusions. NSE administration (10,0 mg / kg) in rats under the combined influence of ionizing radiation (6 Gy) and emotionally-algesic stress slows down the course of regenerative processes and accelerates the depletion of the hematopoietic system, proving for its radiosensitizing effects.

Key words: rats-male, N-stearoilethanolamine, ionizing radiation, stress, hematological parameters, peripheral blood.

Problems of radiation medicine and radiobiology. 2014;19:441-449.