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Effect of low dose ionising radiation and nitric oxide on the state of animal blood system
N. Rodionova, O. Ganzha, L. Makovetska, M. Druzhyna, I. Muzalov, V. Mikhailenko
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, 45, Vasylkivska str., 03022, Kyiv, Ukraine
Objective: to investigate the effects of a prolonged influence of nitric oxide and low dose ionizing radiation on the blood system.
Materials and methods. Adult random$bred male rats 120–150 g of body weight. Animals were treated with different factors: inhalation of nitric oxide for 1 month (14 h per day), fractionated X$ray irradiation (1.0 Gy total absorbed dose), and joint impact of both factors. Hematological, biochemical and biophysical parameters were investigated.
Results. Prolonged action of nitric oxide and low dose ionizing radiation on the state of animal blood system was asayed. The radioprotective effects of nitric oxide on morpho-functional parameters was shown. These effects emerged in the reaction of erythroid hematopoetic pool and lymphocyte series at a level of disorders of oxidative metabolism, decrease of atypical lymphocytes content in peripheral blood.
Conclusion. Nitric oxide within joint prolonged impact with low dose ionizing radiation makes a radioprotective effect on the blood system. Сombined effect of these factors is characterized by the influence on different metabolic pathways and results in better adaptation than under their separate impact.
Key words: low dose ionizing radiation, nitric oxide, blood system, free$radical processes.
Problems of radiation medicine and radiobiology. 2013;18:366–372.
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