Problems of Radiation Medicine and Radiobiology

Combined effect of N-stearoyiletanolamine and ionizing radiation on hematological indices of peripheral blood in rats

N. К. Rоdionova1, N. P. Аtаmaniuk1, L. P. Dеrev’yanko1, V. V. Tal’ko1, A. M. Yanina1, M. V. Shelkovskiy1, G. V. Kosyakova2, O. Ph. Mehed’2, N. M. Gula2, А. А. Chumak1
1State Institution “National Research Center for Radiation Medicine of the National Academy of Medical
Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
2A.V. Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv

The study objective was to explore the peculiarities of peripheral blood values in rats under the combined influence of 10.0 mg/kg N-stearoylethanolamine (NSE) and 6.0 Gy dose of ionizing radiation to identify the radiomodifying properties of the drug.
Methods: hematological, statistical.
Results: it was found that NSE injection to irradiated rats leads to exacerbation of hematopoietic system disorders indicating to radiosensitizing effect of the substance.
Conclusions. The radiosensitizing effect of the drug was established according to qualitative and quantitative abnormalities in peripheral blood values of the rats. Effect of the NSE drug on the rate of recovery processes (i.e. retardation) in the peripheral blood of rats after irradiation was established under these experimental conditions.

Key words: N-stearoyilethanolamine, ionizing radiation, hematological parameters, peripheral blood.

Problems of radiation medicine and radiobiology. 2013;18:356–365.