Problems of Radiation Medicine and Radiobiology

Experimental study of radiomodifying properties of N-stearoilethanolamine under a combined impact of ionizing radiation and stress

L. P. Dеrevyanko1, M. V. Shelkovskiy1, V. V. Tal’ko1, N. P. Аtаmaniuk1, N. O. Frolova1, G. V. Kosyakova2, O. F. Mehed’2, N. M. Gula2, А. А. Chumak1
1State Institution “National Research Center for Radiation Medicine of the National Academy of MedicalSciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
2A.V. Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv

Objective – to investigate the radiomodifying properties of N-stearoilethanolamine (NSE) in experiment under different conditions of a combined impact of ionizing radiation and stress.
Methods: biochemical, statistical.
Results. The radiomodifying properties of N-stearoilethanolamine were revealed under different conditions of a combined impact of ionizing radiation and stress according to the indices of plasma concentrations of TBA-active products, nitrite-anions and catalase activity.
Conclusions. The radioprotective properties of NSE at a dose of 10.0 mg/kg before and after a single total 6.0 Gy irradiation of animals. The radioprotective properties of NSE are identified at a dose of 10.0 mg/kg of animal bodyweight before and after stress. The radiosensitizing properties of NSE occur upon the drug administration in a dose of 10.0 mg/kg before the combined impact of 6.0 Gy ionizing radiation and stress.

Key words: male rats, N-stearoilethanolamine, ionizing radiation, stress, TBA-active products, catalase, nitrite anion.

Problems of radiation medicine and radiobiology. 2013;18:322–329.