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Analysis of some risk factors for myocardial infarction in a cohort of the Chornobyl clean-up workers (according to the data of Clinical and Epidemiological Registry)
A. A. Chumak, G. V. Pleskach
State Institution “National Research Center for Radiation Medicine of the National Academy of MedicalSciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
The objective of the paper was to analyze the individual risk factors for coronary heart disease in a group of clean-up workers, who had developed a myocardial infarction (MI) after the Chornobyl NPP accident.
Methods. Data of 525 clean-up workers with a first MI event were analyzed among all uniquely identifiable clean-up workers registered in the Clinical and Epidemiological Registry (CER) of NRCRM. The comparison was carried out with a control group of 110 residents of Kyiv, who had MI within 2004–2009.
Results. It was found that the proportion of patients who had MI under 45 years was increased in the first 10 years after the Chornobyl accident, being first of all due to the age structure of the clean-up worker’s cohort as a whole. The distribution of patients by age in the following years was close to that in the other MI cohorts described in the literature. The external radiation dose of men who developed MI in the first 5 years after the Chornobyl NPP accident was 39.58±6.72 cSv (median 25 cSv) which exceeded the dose of men who had got the MI later (23.78±2.43 cSv, median 12 cSv; p=0.009).
Conclusions. The quantity of the male patients with minimum number of risk factors was gradually reducing along with time since the Chornobyl accident and accordingly the proportion of patients with three or more risk factors was increased (p=0.001). Incidence of obesity and hypercholesterolemia among male clean-up workers was higher than in the control group of male inhabitants of Kyiv.
Key words: Chornobyl NPP accident, clean-up workers, myocardial infarction, risk factors.
Problems of radiation medicine and radiobiology. 2013;18:289–298.
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