Problems of Radiation Medicine and Radiobiology

Clinical importance of the nonalcoholic fatty liver disease: a review

A. A. Chumak, L. M. Ovsyannikova, E. A. Sarkisovа, E. V. Gasanovа
State Institution “National Research Center for Radiation Medicine of the National Academy of MedicalSciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine

Literature data analysis summarizing features and peculiarities of clinical presentation, pathways and complications of the nonalcoholic fatty liver disease is presented. The key role of insulin resistance, lipid and carbohydrate metabolic disorders, lipid peroxidation and abnormal antioxidant defense system is described. Clinical importance of non-alcoholic fatty liver disease is essential because of a widespread comorbidity and imbalance in the key regulatory body systems.

Key words: nonalcoholic fatty liver disease, metabolic syndrome, clinical importance.

Problems of radiation medicine and radiobiology. 2013;18:277–288.