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SOMATIC CHROMOSOMAL MUTAGENESIS FROM PATIENTS WITH THYROID CANCER, SUFFERED DUE TO THE CHORNOBYL ACCIDENT
[Article in Ukrainian]
V. M. Shkarupa, L. V. Neumerzickaya, Yu. V. Antonenko, O. V. Tepla, S. V. Klymenko*
State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: SergiiV. Klymenko, e-mail: klymenko_sergiy@yahoo.co.uk
The relationship between the presence of high frequencies of chromosomal aberrations in peripheral lymphocytes and predisposition to cancer has been suggested for some cancer diseases. In thyroid cancer, the few reports available are equivocal. The aim of this study was to assess the possible chromosomal instability in peripheral blood lymphocytes from patients with thyroid cancer, suffered due to the Chornobyl accident. For this purpose the chromosomal aberrations assay was applied. The frequency of chromosomal aberrations was 2,66±0,33 (mean value SE) for the patients group with thyroid cancer, suffered due to the Ñhornobyl accident versus 1,47±0,39 in the control group (healthy donors). The frequency of chromosomal aberrations was 2,74±0,49 for the patients group with thyroid cancer, which has not been suffered due to the Ñhornobyl accident. The results obtained revealed no significant differences between all investigated groups. The present study supports the assumption that chromosomal instability in peripheral blood lymphocytes is not visible in thyroid carcinomas using classic cytogenetic chromosomal aberrations assay.
Key words: somatic chromosome mutagenesis, thyroid cancer, Chornobyl accident.
Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.352–358.
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