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NON-INVASIVE METHOD OF EVALUATION OF HEPATIC FIBROSIS IN PATIENTS AFFECTED BY THE CHORNOBYL ACCIDENT WITH CHRONIC DIFFUSE DISEASES OF LIVER
[Article in Ukrainian]
E. A. Sarkisova*, Ye. V. Gasanova, T. A. Shiyko, A. V. Zelinskaya, L. I. Shedenko
State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, 53, Melnykov str., Kyiv, 04050, Ukraine
*Corresponding author: Eleonora A. Sarkisova, e-mail: sarkisova57@ukr.net
There was performed an evaluation of hepatic fibrosis in patients with chronic diffuse diseases of liver, using FibroTest and APRI test. In patients affected by the Chornobyl accident the stage of fibrosis F1–3 (non-classified fibrosis) was detected in 17.4%, the stage F4 (manifested fibrosis) — in 18% of cases; in patients of reference group these indexes were 19% and 21.4% respectively. The stage of fibrotic changes in liver had correlative association with indirect serological markers of fibrosis — levels of ALT, AST, ACT/ALT, total bilirubin, GGTP, albumin, thymol test, cholesterin, hemoglobin, trombocytes, erythrocytes, leukocytes and blood sedimentation rate. Methods FibroTest and APRI are applicable for non-invasive diagnostics of hepatic fibrosis in patients affected by the Chornobyl accident with chronic diffuse diseases of hepatic — steatohepatitis, chronic hepatitis, and also for differential diagnosis of hepatic cirrhosis.
Key words: affected by the Chornobyl accident, hepatic fibrosis, fibrotests.
Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.274–284.
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