Problems of Radiation Medicine and Radiobiology

THE FREQUENCY ANALYSIS OF THE MOST COMMON MUTATIONS IN GENES BRCA1  AND BRCA2 IN WOMEN, WHICH TOOK PART IN THE LIQUIDATION OF CHORNOBYL DISASTER CONSEQUENCES
[Article in Ukrainian]
L. A. Rybchenko, A. M. Bychkova, G. V. Skyban, N. E. Yaroshenko, S. V. Klymenko*
State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: SergiiV. Klymenko, e-mail: klymenko_sergiy@yahoo.co.uk

The frequency of mutations in genes BRCA1 and BRCA2 was investigated among women-liquidators of Chornobyl disaster consequences; the 5382insC mutation of the BRCA1 gene is dominant among the studied spectrum of mutations (it’s frequency is 5.9% in the group of women with breast cancer (BC) and 1.1% in the group of women without BC.

Key words: breast cancer, mutations, BRCA1 and BRCA2 genes, DNA-analysis, clinical and genealogical research, Chornobyl disaster.

Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.267–273.