Problems of Radiation Medicine and Radiobiology

CLINICAL RISK FACTORS AND GENETIC DETERMINANTS OF THROMBOSIS IN PATIENTS WITH Ph-NEGATIVE MYELOPROLIFERATIVE NEOPLASMS
[Article in Ukrainian]
O. Y. Mishcheniuk, O. M. Kostukevich, T. F. Liubarets, S. V. Klymenko*
State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
SSE “Scientific and Practical Center of Preventive and Clinical Medicine” PA, Kyiv
*Corresponding author: SergiiV. Klymenko, е-mail: klymenko_sergiy@yahoo.co.uk

In the study the role of a factor of age over 60 years, leukocytosis, mutation of JAK2 V617F allelic variant gene G1691A factor V coagulation was defined in the development of thrombotic complications in patients with Ph-negative myeloproliferative neoplasms (Ph-negative MPN), namely essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF), who had experienced radiation exposure due to the Chornobyl accident. The age older than 65 years (RR=2,6; 95% confidence interval [CI] 1,15–5,85, p=0,012) and the count of leukocyte higher than the 15.109/L (RR=2,5; 95%, CI=1,45–4,28, p=0,025) are predictors of thrombosis in patients with spontaneous Ph-negative MPN. The Leukocytosis more than 19.109/L in patients with Ph-negative MPN, who had experienced radiation exposure due to the Chornobyl accident, associates with an increase in the relative risk of thrombosis (RR=3,75; 95%, CI=1,5–9,2, р=0,048). The frequency of thrombotic complications in patients with Ph-negative MPN and allelic variant G1691A of factor V is significantly higher than in wild-type defined patient’s (odds ratio=10,1; 95%, CI=7,07–14,28, р=0,049).

Key words: Ph-negative chronic myeloproliferative neoplasms, risk factor for thrombosis, allelic variants G1691A gene of factor V of coagulation.

Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.241–247.