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THE RADIOGENIC ENDOCRINE AND METABOLIC DISORDERS
OF MINERAL AND PROTEIN METABOLISM IN PERSONS HAVING HIGH ABSORBED RADIATION DOSES AFTER THE ChPP ACCIDENT (long-term survey)
[Article in Russian]
Î. Ì. Kovalenko1, I. N. Muravjova1, V. V. Kovalenko2
1State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
2National Aerospace University, Kyiv
*Corresponding author: Iryna N. Muravjova, e-mail: imuraviova@gmail. com
Evaluation of hormonal regulation of bone tissue and type 1 collagen metabolism was the study goal among the ChNPP accident clean-up workers exposed to radiation in absorbed dose range 0.25–7.1 Gy. The non-radiation contributive osteopenic factors were considered too. Male survivors of ARS after the ChNPP accident (1.0–7.1 Gy radiation doses), ChNPP accident clean-up workers (0.25–0.99 Gy radiation doses) and persons having no accident contact with radiation were the study subjects. Disorders of hormonal regulation after radiation impact had led to abnormalities of mineral and protein metabolism in many survivors. The mentioned abnormalities were closely related pointing to hazardous effect of radiation to both organic and inorganic components of extracellular bone matrix and metabolism (synthesis and degradation) of type 1 collagen, its accumulation in myocardial interstitium resulted in intensification of fibroplastic processes. All that predispose to bone remodeling and deterioration of myocardial elastic response being basic for rapid progression of heart failure.
Key words: ionizing radiation, hormonal regulation, mineral and protein metabolism, the ChNPP accident clean-up workers.
Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.183–195.
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