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CLINICAL FEATURES AND RISKS OF TYPE 2 DIABETES MELLITUS OCCURRENCE IN PATIENTS WHO SURVIVED ACUTE RADIATION SYNDROME (25 years after the accident at the Chornobyl NPP)
[Article in Ukrainian]
D. Î. Belyi*, G. V. Dubrovina, V. V. Belaya, I. V. Samoylova, Î. Ì. Kovalenko
State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: Davyd Î. Belyi, e-mail: dbelyi_2000@yahoo.com
The goal of present investigation was to study general features of diabetes mellitus second type as well as risk factors of this disease occurrence in 91 patients survived acute radiation syndrome (ARS) of different grade of severity (radiation doses 1.0–4.5 Gy) and in 128 persons of Chornobyl NPP clean-up staff with radiation doses 0.1–1.4 Gy that were not typical for radiation bone marrow system and didn’t cause ARS. Starting from 1986 the patients of both groups regularly examined according the same schema and extent in the hospital of SI “NRCRM of NAMS of Ukraine”. It was revealed that ARS survivors suffered from diabetes mellitus more frequently than Chornobyl clean-up staff. Occurrence of diabetes mellitus was connected with such factors as patients’ age, hypercholesterolemia and hypertriglyceridemia but not a radiation dose. During 25 years follow up period the patient’s age, body mass index and cholesterol value (mentioned according the increase of significance) determined the risk of diabetes mellitus occurrence. The clinical course of diabetes mellitus was classified as mild and moderate in both patients’ groups. Diabetic retinopathy and polyneuropathy of lower extremities as complications of diabetes mellitus were revealed in 10.7% of patients.
Key words: accident at the Chornobyl NPP, acute radiation syndrome, diabetes, hypercholesterolemia, hyperinsulinemia.
Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.144–154.
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