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CELLS EFFECTS UPON COMBINED INFLUENCE OF HEAVY METALS SALINS AND IONISING RADIATION
[Article in Ukrainian]
G. I. Lavrenchuk
SI “ National Research Center for Radiation Medicine National Academy of Medical Sciences of Ukraine”, Kyiv
The experimental studies of with ionizing radiation in different doses were studied. The lead cytotoxicity by indices of cells proliferative and mitotic activity in culture was significantly higher than the cytotoxity of nickel. Irradiating of cells in the presence of lead showed more damaging effect then when lead was added after the ionizing radiation, cells sensitisation was observed. Nickel ions presence under cells irradiation lead to viability, proliferative and mitotic activity increase comparing to action of nickel by itself. Irradiation in these conditions could play the role of adapting factor. The greatest effect was observed upon irradiation in sublethal dose of 10 Gy. However apoptosis determination in cells cultures upon combined influence of ionizing radiation and heavy metals showed that ñells incubation with nickel ions induced apoptosis twice as more as while cells were incubated with lead ions, especially on range of low concentrations and high irradiation doses.
Key words: heavy metals, irradiation, cell culture, viability, mitosis, apoptosis.
Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P. 292–302.
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