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CYTOGENETIC PECULIARITIES AND VASCULAR ENDOTHELIUM GROWTH FACTOR BLOOD CONCENTRATION IN MYELODYSPLASTIC SYNDROME PATIENTS SUFFERED DUE TO CHORNOBYL NPP ACCIDENT
[Article in Ukrainian]
Ò. F. Liubarets, Ì. À. Pilinska, J. Ì. Ìinchenko, L. À. Ìisharina, V. G. Fedorenko
SI “National Research Center for Radiation Medicine, National Academy of Medical Sciences of Ukraine”, Kyiv
Normal karyotype in 14 from 20 patients with MDS was observed. In 3 exposed individuals non-clonal structural chromosomal aberrations were revealed. In 3 patients (one resident of contaminated area and two unirradiated persons) clonal chromosome abnormalities were recorded. VEGF blood concentration in irradiated MDS patients was significantly lower than in non-exposed ones, in irradiated CMML patients it was significantly higher. The presence of high correlations between cytogenetic effects, VEGF blood concentration and main indices of peripheral blood and bone marrow confirmed their predictive value for MDS acceleration.
Key words: chromosome, karyotype, chromosome aberrations, vascular endothelium growth factor, myelodisplastic syndrome, Chornobyl NPP accident.
Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P. 242–254.
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