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MYELOPROLIFERATION MARKERS FOR PROGNOSIS OF PRIMARY AND RADIATION-ASSOCIATED MYELOFIBROSIS WITH MYELOID METAPLASIA
[Article in Ukrainian]
I. M. Prokopenko
SI “National Research Center for Radiation Medicine, National Academy of Medical Sciences of Ukraine”, Kyiv
The analysis of myeloproliferative characteristics of 55 patients with radiation-associated myelofibrosis and 47 patients — with spontaneous myelofibrosis with myeloid metaplasia were presented. Taking into account individual radiation doses, absorbed after the Chornobyl accident, disease stages, expected living median in 14-year observation interval, index of myeloproliferation and myelodepression, subgroups of good, interim and bad prognosis for the disease course were singled out, the radiation affect on myelopoiesis with consideration of the disease dynamics were assessed.
Key words: myelofibrosis with myeloid metaplasia, radiation, myeloproliferation markers.
Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P. 236–241.
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