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THE ROLE OF HEPATITIS C VIRAL INFECTION IN REALIZATION OF NEGATIVE INFLUENCE OF XRCC1 GENE POLYMORPHISM ON DEVELOPMENT OF CHRONIC NON-CANCER DISEASES IN CHORNOBYL CATASTROPHE SUFFERERS
[Article in Ukrainian]
À. À. Chumak, I. V. Abramenko, N. I. Bilous, A. V. Kostin,
Î. Ya. Pleskach, V. M. Polianska, L. M. Greñhana
SI “National Research Center for Radiation Medicine, National Academy of Medical Sciences of Ukraine”, Kyiv
The aim of paper — to analyze a possible influence of viral hepatitis C (HCV) infection on development of somatic diseases in carriers of Arg399Gln XRCC1 gene’s polymorphisms. Ninety four sufferers of Chornobyl NPP accident were observed. Arg399Gln XRCC1 gene’s polymorphisms were studied by polymerase chain reaction with restriction of products. The increased frequency of chronic gastritis (p=0.001), chronic hepatitis (p=0.001) and non-cancer thyroid diseases (p=0.036) was revealed in carriers of Gln399Gln homozygous genotype. The influence of polymorphism was found only in HCV-infected persons, while the differences in distribution of somatic diseases in non-infected carriers of different genotypes were insignificant. It was concluded that preventive and curative measures for HCV elimination are needed.
Key words: DNA repair genes, XRCC1, ionizing radiation, chronic hepatitis, somatic diseases, acute radiation syndrome convalescents, clean-up workers of Chornobyl NPP accident.
Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P. 156–163.
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