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K. V. Kuts, H. Yu. Kreinis, I. V. Perchuk, K. Yu. Antypchuk, Z. L. Vasylenko, V. I. Kravchenko,
N. V. Drozdova
State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine
NEUROPSYCHIATRIC AND PSYCHOGENETIC ASPECTS OF POST-TRAUMATIC STRESS DISORDERS ASSOCIATED WITH THE CHORNOBYL DISASTER AND THE RUSSIAN-UKRAINIAN WAR: FOCUS ON THE ENDOCANABINOID SYSTEM
This review article is devoted to neuropsychiatric and psychogenetic aspects of post'traumatic stress disorder
(PTSD) in the context of traumatic scenarios of the Chornobyl disaster and the Russian'Ukrainian war.
Unprecedented challenges associated with man'made, socio'political, and military emergencies contribute to the
significant spread of mental disorders among the military and civilian populations of Ukraine. Combined with significant difficulties in treatment and the limited effectiveness of existing treatment strategies, there is a serious
clinical gap in the diagnosis and management of PTSD. Therefore, research into the genetic and epigenetic markers
of this disorder, the creation and implementation of PTSD prevention models, followed by the development of individualized therapeutic and rehabilitation strategies aimed at reducing the duration of treatment, improving its
effectiveness, and facilitating patient adaptation in society, remains an extremely relevant problem in clinical neuroscience. Particular attention is paid to the endocannabinoid system as a potential target for therapeutic intervention in PTSD, promising research directions, and the possibilities for the therapeutic use of cannabinoids in clinical
practice.
Key words: Chornobyl disaster; participants in the liquidation of the consequences of the accident at the Chornobyl
Nuclear Power Plant; Chornobyl clean'up workers; post'traumatic stress disorder (PTSD); Armed Forces of Ukraine
(AFU); psychogenetics, neuropsychiatry; Russian'Ukrainian war; endocannabinoids.
Problems of Radiation Medicine and Radiobiology.
2025;30:32-68. doi: 10.33145/2304-8336-2025-30-32-68
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