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S. V. Masiuk1, Ì. ². Chepurny1, V. B. Buderatska1, Î. Ì. Ivanova1, Z. N. Boiko1, N. S. Zhadan1,
H. V. Chornovol1, M. Yu. Bolgov2, V. M. Shpak2, M. D. Tronko2, T. I. Bogdanova2, D. Karyadi3,
V. Vij3, E. K. Cahoon3, S. J. Chanock3, L. M. Morton3, V. Drozdovitch3
1State Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the
National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine
2State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy
of Medical Sciences of Ukraine», 69 Vyshhorodska St., Kyiv 04114, Ukraine
3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical
Center Drive, Bethesda, MD 20892, USA
INDIVIDUAL THYROID DOSE ESTIMATES FOR THE GENOMIC STUDY OF FOLLICULAR CARCINOMAS AND ADENOMAS IN PARTICIPANTS OF THE CHORNOBYL TISSUE BANK
Objective. Assessment of thyroid doses among participants of the Chornobyl Tissue Bank (CTB) enrolled in the study
of the genomic landscape of thyroid follicular carcinomas and follicular adenomas, using updated methodologies and
data on residential history and dietary patterns collected during the study through personal dosimetry interviews.
Materials and methods. This study presents an assessment of thyroid doses in 140 participants of the Chornobyl
Tissue Bank (CTB) with pathologically confirmed diagnoses of follicular adenoma and follicular thyroid carcinoma.
Thyroid doses from 131I intake were estimated using the substantially revised ‘Thyroid Dosimetry System 2020 for
Ukraine’ (TDU20). In addition, the data on residential and dietary history have been obtained through personal
interviews with 85 individuals for whom dosimetry-related data were limited. Radiation doses to the thyroid were
also estimated for the following minor exposure pathways: (a) intake of short-lived radionuclides (132Te+132I and 133I)
via inhalation and ingestion; (b) external irradiation from radionuclides deposited on the ground; and (c) ingestion
of 134Cs and 137Cs with contaminated foodstuffs.
Results. The arithmetic mean of thyroid doses estimated in this study from all exposure pathways combined was
445 mGy, while the median dose was 71 mGy. Among study participants, a broad range of thyroid doses was observed,
from 0.23 mGy to 14 Gy. The major exposure pathway was 131I intake, which accounted for a median contribution of
92 % to the thyroid dose. Among individuals who were interviewed in the study, thyroid doses from 131I intake that
were calculated using TDU20 and individual questionnaire data were lower than doses that did not include the interview data: 105 mGy vs. 150 mGy for the arithmetic mean and 46 mGy vs. 98 mGy for the median, respectively.
Uncertainties in dose estimates from 131I intake were characterized using the geometric standard deviation of 1,000
individual stochastic dose realizations. As a result, the geometric standard deviation ranged from 1.3 to 6.1, with an
overall arithmetic mean of 3.1 and a median of 3.3 across all study participants.
Conclusions. This study demonstrated that the use of individual questionnaire data in dose assessment for participants who completed personal dosimetric interviews had an impact on the estimated thyroid doses. In conducting
specialized studies aimed at identifying potential associations between thyroid dose and key demographic, clinical,
pathological, and molecular-genetic indicators, it is valuable to carry out personal dosimetric interviews to obtain
detailed residential and dietary histories of study participants. Incorporating such information allows for more realistic individual dose estimates.
Key words: Chornobyl Tissue Bank, Chernobyl, radiation dose, thyroid, dosimetry interview.
Problems of Radiation Medicine and Radiobiology.
2025;30:186-217. doi: 10.33145/2304-8336-2025-30-186-217
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