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L. V. Neumerzhytska, D. A. Kurinnyi, V. V. Talko, M. H. Romanenko
State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine
BIOMARKERS OF RADIATION-INDUCED GENOMIC INSTABILITY IN SOMATIC CELLS
The review highlights current ideas about the mechanisms of radiation-induced genome instability formation.
Based on the results of a search in the abstract medical and biological database PubMed/MEDLINE, Google Scholar
and a manual search of relevant information sources, data on the use of some cytogenetic and molecular genetic
methods as biomarkers of the effects of low-dose acute and prolonged radiation are analyzed and summarized. The
effectiveness of the use of natural radioprotectors under various radiation conditions (emergency, professional,
radiotherapy, etc.) is considered. The search results confirm the feasibility of studying the radiation-induced effect
at the cytogenetic, genomic and epigenomic levels, which will contribute to solving an important problem in radiobiology, radiation genetics and radiation protection to improve methods for assessing, predicting and preventing the
negative effects of radiation on human health.
Key words: ionizing radiation, genome stability, epigenetic.
Problems of Radiation Medicine and Radiobiology.
2025;30:105-125. doi: 10.33145/2304-8336-2025-30-105-125
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