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T. F. Liubarets
Bogomolets National Medical University, Taras Shevchenko Blvd, 13, Kyiv, 01024, Ukraine
TR53 AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND PROGNOSIS OF THE COURSE OF ACUTE MYELOID LEUKEMIA (literature review)
The review presents literature data on the role of the ТР53 gene and ionizing radiation (IR) in the pathogenesis of
acute myeloid leukemia (AML).The violation of ТР53 functioning as a promoter of AML induction under the influence
of negative external factors (IR, chemotherapeutic agents) was analyzed. New directions of AML stratification are
presented, which will allow to optimize the future therapy and extend the life expectancy of this category of
patients.
Key words: acute myeloid leukemia, treatment options, ТР53, ionizing radiation.
Problems of Radiation Medicine and Radiobiology.
2024;29:67-78. doi: 10.33145/2304-8336-2024-29-67-78
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