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L. I. Shvaiko, K. D. Bazyka, M. V. Shilenko, A. A. Savchenko, N. A. Tkachuk
State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the
National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine
PATTERNS OF DEVELOPMENT OF CLINICAL AND FUNCTIONAL DISORDERS OF THE BRONCHOPULMONARY SYSTEM IN THE POST-ACCIDENT PERIOD IN PERSONS EXPOSED TO IONIZING RADIATION
The objective of the study was to establish the relationship between functional status of bronchopulmonary system
and obstructive sleep apnea in clean-up workers of Chornobyl NPP accident in a remote post-accident period.
Materials and methods. A retrospective analysis of 824 cases of COPD in male patients who underwent inpatient
treatment in the radiation pulmonology department from 2014 to 2024 was conducted. The observation groups
included 579 (70.3%) of urban residents (main group) and 245 (29.7%) of COPD patients (nosological control) who
were irradiated within the natural background. For prospective observation, 100 COPD patients from urban residents
and 30 COPD patients from the NC group were selected. A complex of clinical and functional tests was provided.
Results. In clean-up workers of Chornobyl NPP accident with COPD The regularities of damage to the bronchopulmonary system under the influence of ionizing radiation should be considered a change in the minimal clinical
symptoms of the early period, the rapid development of fibrotic changes in the lungs and bronchial mucosa, which
is accompanied by a deepening of violations of functional pulmonary tests, structural and morphological changes
according to the results of radiological research methods.
Conclusions The analysis of various patterns and phenotypes of COPD requires further study in order to improve
early diagnosis and treatment of the disease, in particular in people who have suffered as a result of exposure to
ionizing radiation.
Key words: clean-up workers of Chornobyl NPP accident, pulmonary function tests.-
Problems of Radiation Medicine and Radiobiology.
2024;29:425-434. doi: 10.33145/2304-8336-2024-29-425-434
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