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D. A. Bazyka1, K. M. Bruslova1, L. O. Lyashenko1, T. I. Pushkareva1, N. M. Tsvyetkova1,
S. G. Galkina1, V. G. Kondrashova1, Zh. S. Yaroshenko1, L. O. Gonchar1, V. D. Pismenniy2,
I. V. Trychl³b1, S. M. Yatsemyrskyi1, V. G. Boyarskyi1, T. O. Chernysh1, O. M. Ivanova1,
S. H. Horbachov1
1 State Institution «National Research Center of Radiation Medicine, Hematology and Oncology of the
National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine
2 O. O. Bogomolets Memorial National Medical University, 13 Taras Shevchenko Blvd, Kyiv, 01024,
Ukraine
CORRECTION CRITERIA FOR THE BONE TISSUE STRUCTURE DISORDERS IN CHILDREN LIVING IN RADIOLOGICALLY CONTAMINATED TERRITORIES AFTER THE CHORNOBYL NPP ACCIDENT
Objective. To determine the structure of abnormalities of bone tissue and substantiate the management tactics in
acute lymphoblastic leukemia (ALL) pediatric patients and in children with no oncohematological disorders, living
in radiologically contaminated territories (RCT).
Materials and methods. Children (n = 220) living in RCT were the study participants i.e. the ALL patients (n = 120,
Group I) and ones with no oncohematological disorders but having got some abnormalities in osteon and iron
metabolism (n = 100, Group II). There were 81.7 % cases of the «common» ALL, 10.0 % of the pro-B-ALL, and 8.3 %
of the T-ALL types. Incidence of the bone fractures and jaw anomalies were taken into account. Types of
diseases/disorders in the children’s relatives were identified. The hemogram and myelogram data were evaluated.
Biochemical blood parameters, namely the total protein, creatinine, calcium, alkaline phosphatase, serum iron (SI),
ferritin (SF), transferrin, and vitamin D serum content along with the amino acid content in urine, bone mineral density (BMD) value, serum level of pituitary thyroid-stimulating hormone (TSH), free thyroxine, and cortisol were
assayed. Individual radiation doses were calculated/reconstructed. Curative and preventive measures were developed and applied.
Results. Collagen degradation, increased urinary excretion of oxyproline and proline, and decreased level of glycine
and lysine occurred in the Group I after the chemotherapy (ChT) administration. The number of patients with BMD
lower than 65 relative units (RU) was increasing (p < 0.05) as well as the number of cases with body iron excess
(41.7 %). Toxic hepatitis and fatal cases were more often observed (p < 0.05 and r = -0.38, p < 0.01 respectively)
under the SF level above 500 ng/ml. A direct relationship was established between the serum levels of SF and cortisol (r = 0.55; p < 0.05), between the TSH levels (above 3.3 IU/l) in blood serum and oxyproline in urine (r = 0.39;
p < 0.05) negatively affecting the state of collagen. An increased level of cortisol contributed to the abnormalities
in bone tissue structure and to a worse prognosis of the ALL course (p < 0.01). In the Group II (subjects having got
bone structure abnormalities) the sum amount of amino acids was increased. In 30.0 % of them the SI level exceeded the normative range. Radiation doses were on average (4.5 ± 0.9) mSv in ALL patients and (0.78 ± 0.07) mSv in
the RCT residents with no correlation with either serum biochemical parameters or BMD values. Curative and preventive measures were aimed at correcting the protein deficiency and mineral component of bone tissue, removing
excess iron from the body, and normalizing of hormonal status. Positive effect was reached in 81.7 % of the ALL
patients 6 months after the end of ChT. Normalization of the studied parameters occurred in 80 % of children having no oncohematological disorders.
Conclusions. Diagnosis of abnormalities in the bone tissue structure and correction of osteogenesis in children
reveal the mechanisms of leukemogenesis, determine the algorithm for timely approaches in prevention of blood
system diseases, and improve the quality of life of children.
Key words: children, Chornobyl accident, osteogenesis markers, iron metabolism, thyroid gland, cortisol, curative
measures.
Problems of Radiation Medicine and Radiobiology.
2024;29:243-258. doi: 10.33145/2304-8336-2024-29-243-258
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