Problems of Radiation Medicine and Radiobiology

I. O. Selina^1,2, I. S. Dyagil³

¹PI «Dnipropetrovsk City Multidisciplinary Clinical Hospital No. 4» DCC, 31 Blyzhnya street, Dnipro,
49102, Ukraine
²Dnipro State Medical University, 9, Vernadsky Іtr., Dnipro, 49044, Ukraine
³State Institution «National Research Center for Radiation Medicine of the National Academy of Medical
Sciences of Ukraine», 53 Yuria Illienka Str., Kyiv, 04050, Ukraine

THE STRUCTURE OF THE INCIDENCE OF ONCOHEMATOLOGICAL DISEASES IN ECOLOGICALLY DISADVANTAGED REGIONS OF THE DNIPROPETROVSK REGION FOR THE PERIOD 2006–2017

Objective: to conduct a comparative analysis of the incidence of malignant oncohematological diseases structure among the population of the 4 most ecologically disadvantaged cities of the Dnipropetrovsk region, taking into account the possible influence of various adverse environmental factors (radiation and chemical pollution of air, water and soil) for the period 2006–2017.
Materials and methods. 1948 cases of acute myeloblastic and lymphoblastic leukemia, chronic myeloid and lymphocytic leukemia in residents of 4 cities of the Dnipropetrovsk region were analyzed, taking into account the possible influence of adverse environmental factors (radiation, air pollution, etc.). We used clinical and hematological data per patient and statistic information on these diseasis incidence in the region.
Results. An analysis of the oncohematological patients incidence structure, namely: acute lymphoblastic (C91.0) and myeloblastic leukemia (C92.0), chronic lymphocytic (C91.1) and myeloid (C92.1) leukemia, over 12 years in environmentally disadvantaged cities of Dnipropetrovsk region have been conducted. A comparative analysis of the incidence of these diseases among the population of 4 cities of the Dnipropetrovsk region was carried out, taking into account the possible influence of adverse environmental factors (radiation, air pollution, etc.). An excess of the incidence rates of the above-mentioned oncohematological diseases for the period 2006–2017 was revealed in the cities of Dnipro, Kryvyi Rih, Kamianske and Zhovti Vody, where environmental factors significantly affect the increase in morbidity due to pollution mainly by radioactive and chemical substances.
Key words: morbidity, acute lymphoblastic leukemia, chronic lymphocytic leukemia, chronic myeloid leukemia, acute myeloid leukemia, environmental disadvantage, radiation.

Problems of Radiation Medicine and Radiobiology.
2023;28:404-415. doi: 10.33145/2304-8336-2023-28-404-415

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