National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"

ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology



M. O. Tregubova1, . . Rudenko1, V. V. Lazoryshynets1, S. V. Fedkiv1, O. M. Trembovetskaya1,
P. A. Danchenko2, Yu. I. Vitkovsky1, M. S. Ishchenko1, A. Yu. Gavrylyshyn1, V. V. Parfentyeva1,
Yu. Yu. Stukov3

1SI Amosov National Institute of Cardiovascular Surgery of National Academy of Medical Sciences of
  Ukraine, 6 Amosova St., Kyiv, 03038, Ukraine
2Bohomolets National Medical University, 13 Tarasa Shevchenka Blvd., Kyiv, 01601, Ukraine
3Center of Regenerative Medicine, Division of cardiovascular medicine, University of Florida, Gainesville,
  FL 32611, United States


Background. Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. Extended septal myectomy ( ESM) is one of the priority methods of treatment of drug-refractory obstructive HCM. In recent years, hospital mortality during surgical correction of obstructive HCM in expert centers does not exceed 12 %. However, typical threatening complications of septal myectomy, such as iatrogenic ventricular septal defect (VSD) and rupture of the anterior or posterior walls of the left ventricle (LV), remain a topical issue in surgery of HCM.
Objective: to show the role of preoperative CT-planning to predict and reduce possible technical problems associated with ESM, including iatrogenic VSD. Methods and materials. This study includes 217 symptomatic patients with obstructive HCM, who from April 2016 to October 2019 as one of the steps of preoperative planning underwent cardiac CT prior to ESM. Cardiac CT was performed to delineate the left ventricular myocardium, assess the distribution of hypertrophy and the presence of crypts. Special attention was also paid to the anatomy of the mitral valve (MV) and subvalvular apparatus. Coronary artery patency was assessed by CAD-RADS, a standardized method for reporting the results of coronary CT angiography to determine tactics for further management of the patient.
Results and discussion. In the study group, the average age of patients was (49 15) years, 48 % men. All patients had a symptomatic, drug-refractory obstructive form of HCM. The mean maximum wall thickness of the interventricular septum (IVS) was (20 5) mm (range 1633). The average LV mass was (118 23) g/m2. 195 patients (89.9 %) had systolic anterior motion ( SAM) of the MV. MV and subvalvular apparatus anomalies were detected in 62 patients (28.6 %). A zone of scarring and regression of IVS after alcohol septal ablation (ASA) was detected in 7 patients (0.3 %) with residual LV outflow gradient. Coronary arteries atherosclerosis was detected in 32 patients (14.7 %).
Conclusions. Preoperative CT-planning of septal myectomy allows to obtain information on morphology of the LV, IVS, MV and subvalvular apparatus, and gives the surgeon the advantage to form a more accurate plan for the location and volume of septal resection, and avoid complications when correcting obstructive HCM. No iatrogenic VSD was detected in any of the patient in the study group.
Key words: hypertrophic cardiomyopathy, computed tomography, preoperative planning, extended septal myectomy.

Problems of Radiation Medicine and Radiobiology.
2020;25:592-606. doi: 10.33145/2304-8336-2020-25-592-606

full text

Home | Editorial board | For Authors | Archive | Search
© 2013 Problems of Radiation Medicine