National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"

ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology



O. V. Shemetun, M. A. Pilinska

State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine


The review summarizes and analyzes the data of world scientific literature and the results of the own research concerning one of the main non-targeted effects of ionizing radiation – the radiation induced bystander effect (RIBE) – the ability of irradiated target cells to induce secondary biological changes in non-irradiated receptor cells. The history of studies of this phenomenon is presented – it described under various names since 1905, began to study from the end of the twentieth century when named as RIBE and caused particular interest in the scientific community during recent decades. It is shown that the development of biological science and the improvement of research methods allowed to get new in-depth data on the development of RIBE not only at the level of the whole organism, but even at the genome level. The review highlights the key points of numerous RIBE investigations including modeling; methodological approaches to studying; classification; features of interaction between irradiated and intact cells; the role of the immune system, oxidative stress, cytogenetic disorders, changes in gene expression in the mechanism of development of RIBE; rescue effect, abscopal effect, persistence, modification, medical effects. It is emphasized that despite the considerable amount of research concerning the bystander response as the universal phenomenon and RIBE as one of its manifestations, there are still enough «white spots» in determining the mechanisms of the RIBE formation and assessing the possible consequences of its development for human health.
Key words: ionizing radiation, non-targeted effects, radiation-induced bystander effect, classification, mechanisms of development, manifestation, persistence, modification, consequences.

Problems of Radiation Medicine and Radiobiology.
2019;24:65-92. doi: 10.33145/2304-8336-2019-24-65-92

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