Problems of Radiation Medicine and Radiobiology

L. V. Hrechanska^2,3, L. D. Kaliuzhna¹, P.V. Fedorych², A.V. Petrenko¹

¹Shupyk National Medical Academy of Postgraduate Education, 9 Dorohozhytska str., Kyiv, 04112, Ukraine
²Ukrainian Military Medical Academy, 45/1 Moscovskyi lane, Kyiv, 01015, Ukraine
³Kyiv Regional Hospital # 2, 13/19 Nesterivskyi lane, Kyiv, 02000, Ukraine

CLINICAL CASE OF CUTANEOUS T-CELL LYMPHOMA IN A PATIENT WHO GOT INJURED AFTER THE DISASTER ON CHORNOBYL NUCLEAR POWER PLANT

A clinical case of cutaneous T-cell lymphoma is presented in this paper – Mycosis fungoides, a tumorous stage that developed in a patient who suffered as a result of the Chornobyl accident. The most likely development of this disease is due to the influence of the radiation factor, which led to the affection of lymphoid cells. This disease has characteristic staging with a typical morphological pattern only in later stages, therefore, the diagnosis usually occurs in evident clinical and histological changes of the mycotic and tumorous stages, when treatment is ineffective. The features of the disease and treatment are described.
Key words: T-cell lymphoma, Mycosis fungoides, lymphoproliferative diseases, Chornobyl accident, histological examination.

Problems of Radiation Medicine and Radiobiology.
2019;24:516-521. doi: 10.33145/2304-8336-2019-24-516-521

full text

1. Atzmony L, Amitay-Laish I, Gurion R, Shahal-Zimra Y, Hodak E. Erythrodermic mycosis fungoides and Sezary syndrome treated with extracoporealphotophoresis as part of a multimodality regimen: A single-centre experience. J Eur Acad Dermatol Venereol. 2015;29(12):2382-9. DOI: https://doi.org/10.1111/jdv.13243

2. Lukowsky A., Muche IM, Mobs M, Assaf C, Humme D, Hummel M, et al. Evaluation of T-cell clonality in archival skin biopsy samples of cutaneous T-cell lymphomas using the Biomed-2 PCR protocol. Diagn Mol Pathol. 2010;19(2):70-7. DOI: 10.1097/PDM.0b013e3181b2a1b7.

3. Olsen E, Vonderheid E, Pimpinelli N, Willemze R, Kim Y, Knobler R, et al. Revisions to the staging and classification of mycosis fungoies and Cezary syndrome: a proposal of the internatinal Society for Cutaneous Lymohomas (ISCL) and cutaneous lymphoma task force of the European Organization of Research and treatment of Cancer (EORTC). Blood. 2007;110:1713-22. DOI: https://doi.org/10.1182/blood-2007-03-055749.

4. Sanchez-Schmidt JM, Salgado R, Servetje O, Gallardo F, Ortiz-Romero PL, Karpova MB, et al Primary cutaneous CD30+ anaplastic large-cell lymphomas show a heterogeneous genomic profile: An oligonucleotide array CGH approach. J Dermatol. 2011;131:269-71. DOI: https://doi.org/10.1038/jid.2010.271.

5. Thestrup-Pedersen K. Cutaneous T-cell lymphoma. A hypothesis on disease pathophysiology involving deficiency in DNA repair. J Eur Acad Dermatol Venereol. 2016;30:1682-5. DOI: https://doi.org/10.1111/jdv.13852.