Problems of Radiation Medicine and Radiobiology

E. A. Sarkisova¹, A. A. Chumak¹, L. M. Ovsyannikova², L. M. Alekhina¹, O. V. Nosach²,
E. O. Gasanova¹, T. O. Shyiko¹

¹State Institution «National Research Center for Radiation Medicine of the National Academy Medical Sciences of Ukraine», Melnykov str, 53, Kyiv, 04050, Ukraine
²Natsional Academy of Medical Sciences of Ukraine, 53 Melnykova str., Kyiv, 04050, Ukraine

THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON/ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION

Objective: to determine the effectiveness of combined treatment with hepatoprotectors and antioxidant a complex preparation of vitamins A and E (I) in patients with non-alcoholic steatohepatitis (NASH) who suffered from the Chornobyl NPP accident based on the results of evaluation of metabolic changes.
Materials and methods. The state of the hepatobiliary system of 72 patients with NASH suffered as a result of the Chornobyl accident was studied based on the results of the biochemical analysis of blood, indicators characterizing the processes of oxidative modification of macromolecules and the state of the antioxidant system (AOS), as well as structural changes in the liver according to ultrasound investigations in the course of the examination before and after treatment.
Results. The treatment of NASH with hepatoprotectors and antioxidant I in the sufferers of the Chornobyl accident increased the level of antioxidant defense products (catalase and superoxide dismutase) with the normalization of the integral index of the AOS, and a significant decrease in the number of patients with reduced AOS status (from 42.6% to 24.2%, p <0.05), positive dynamics of biochemical parameters of blood with decreasing frequency of detection of cholestasis syndrome, hypercholesterolemia and hyperglycemia were established as well as the positive dynamics of structural changes in the liver according to ultrasound data.
Conclusion. Combined therapy of NASH with hepatoprotectors and antioxidant I in patients who suffered from the Chornobyl NPP accident contributes to the restoration of the prooxidant-antioxidant balance, decreases cholestasis, hypercholesterolemia and hyperglycemia, and promotes positive dynamics of structural changes in the liver.
Key words: treatment, nonalcoholic steatohepatitis, hepatoprotectors, antioxidants, sufferers of Chornobyl NPP accident, metabolic changes.

Problems of radiation medicine and radiobiology.
2018;23:452_461. doi: 10.33145/2304-8336-2018-23-452-461.

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