Problems of Radiation Medicine and Radiobiology

M. M. Tkachenko¹, P. O. Korol^1,2

¹Bohomolets National Medical University, 01601, Kiev, T. Shevchenko Blvd, 13, Ukraine
²Kiev Clinical City Hospital #12, 01103, Kiev, Pidvysotskoho str., 4a, Ukraine

The role of three-phase bone scintigraphy in arthroplasty of hip and knee joints of clean-up workers of Chornobyl accident

Objective. The objective of the work to determine the diagnostic role of the three-phase bone scintigraphy (3-F BS) in the early prediction of paraendoprosthetic complications of the hip and knee joints of the participants in clean-up workers of Chornobyl accident.
Material and methods. The 3-F BS method were investigated the radionuclide kinetic parameters of the inclusion and distribution of radiopharmaceuticals (RF) in damaged joints in the 75 male clean-up workers.
Results. It was established that calculating the quantitative indices of kinetics of the drug at various stages of the 3-F BS allowed to determine statistically significant differences in metabolic changes in focal lesions in articular structures. Thus, the differential diagnostic capabilities of the radionuclide method of examination of patients with arthroplasty of the hip and knee joints are elevated.
Conclusions. The kinetics of osteotropic RF in the foci of fixing the damaged hip and knee joints in the infectious and inflammatory processes is characterized by the predominance of retention and specific accumulation of the drug in the early static phase and the delayed static phase of the 3-F BS compared with the centers of fixation of RF in deforming osteoarthroses, which correlates with the differences in destructive-reparative processes in them.
Key words: bone scintigraphy, arthroplasty, hip and knee joints, radiopharmaceuticals.

Problems of radiation medicine and radiobiology. 2017;22:476–483.