National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"

ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology



E. A. Domina

R. E. Kavetsky Institute of Experimental pathology, Oncology and Radiobiology of NAS of Ukraine,
45 Vasylkivska str., 45, Kyiv, 03022, Ukraine

Early and late radiation effects in healthy tissues of oncologic patients under
therapeutic irradiations

The objective of the article is summarize the literature regarding on the patterns and mechanisms of the formation of early and distant radiation reactions of healthy cells due to the therapeutic irradiation of cancer patients. Particular attention is given to the modern views on the molecular mechanisms of the processes of various repair systems (DDR, BER, NER, MMR, etc.) whose ineffectiveness is associated with radiationinduced instability of the genome of healthy cells and the etiology of secondary tumours of radiation genesis in cancer patients as a result of radiation therapy. Solving the problem of individual radiation sensitivity of an organism of cancer patients will help to reduce the frequency of early and late radiation complications.
Key words: oncologic patients, radiation therapy, healthy cell responses, smoothing, secondary tumours.

Problems of radiation medicine and radiobiology. 2017;22:23-37.

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