Problems of Radiation Medicine and Radiobiology

Ye. I. Stepanova, I. Ye. Kolpakov, V. M. Zyhalo, V. G. Boyarsky

State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Melnykova Street, Kyiv, 04050, Ukraine

Correction of endothelial dysfunction in children-residents of radioactively contaminated areas by nitric oxide donator

Objective: to determine the effectiveness of NO-L-arginine donator for correcting endothelial dysfunction in children-residents of radioactively contaminated areas.
Materials and Methods. A group of children-residents of radioactively contaminated areas with the presence of clinical and paraclinical signs of endothelial dysfunction was selected to assess the effectiveness of correcting endothelial dysfunction by NO-L-arginine donator according to selective screening. Biochemical parameters for the content of stable NO metabolites, serum L-arginine; instrumental parameters of endothelium dependent vascular reaction on occlusion test, the ventilation capacity of the lungs were determined. A course of NO-BetarhinТ dona- tor, which active substance is L-arginine, was received by examined children.
Results and Conclusions: A group of children-residents of radioactively contaminated areas with the presence of clinical and paraclinical signs of endothelial dysfunction was selected according to selective screening. The pro- nounced positive therapeutic effect, good tolerability, absence of side effects were observed in children with endothelial dysfunction, who were received a course of NO-L-arginine donator. It has been established that L-argi- nine use contributed to increasing the content of serum arginine, nitrite, nitrate, and amounts of NO metabolites in children with endothelial dysfunction. Bronchospasm elimination was noted after L-arginine use in the significant part of examined patients. An increase in the diameter of the brachial artery and its space in the test with post occlusion reactive hyperemia after the use of L-arginine course was revealed by an evaluation of indicators for endothelium dependent vasodilatation of the large vessels using ultrasound method visualizing the brachial artery lumen. This indicates an increase in endothelial vasomotor capacity.
Key words: children, radioactively contaminated territories, endothelial dysfunction, correction, nitric oxide donator.

Problems of radiation medicine and radiobiology. 2016;21:336–344.