Problems of Radiation Medicine and Radiobiology

Efficiency of endothelial dysfunctioncorrection in children-residents of radioactively contaminated areas using the method of intermittent normobaric hypoxi therapy

Objective is to evaluate the effectiveness of intermittent normobaric hypoxi therapy as the means that can posi- tively influence on the different links in the pathogenesis of endothelial dysfunction in children-residents of radioactively contaminated areas.
Materials and methods. Disorders of personal and emotional sphere, symptoms of asthenic vegetative and neurot- ic character, the signs of the cardiovascular and respiratory systems, abdominal and dyspeptic syndromes are attrib- uted to the clinical signs of endothelial dysfunction. There were determined the biochemical parameters of the con- tent of stable metabolites of NO, L-arginine, lipid peroxidation, antioxidant enzymes in the blood serum; the indices of cellular and humoral immunity; the instrumental indices of vascular endothelium-dependent reaction to occlu- sion test, ventilating ability of the lungs, the bioelectric activity of the myocardium. Intermittent normobaric hypoxi therapy (INHT) was performed using the individual device of mountain air of the «Borei» type produced by State Research Medical Engineering Center «NORT» NAS of Ukraine (Kyiv).
Results and conclusions. The clinical examination showed that the administration of additional intermittent nor- mobaric hypoxi therapy to the basic treatment of 44 children with endothelial dysfunction who live in the radioac- tively contaminated areas, promoted to reduce the frequency of complaints and intensity of clinical manifestations in the mentioned symptom complex. An increase of serum L-arginine in the absence of significant changes in the content of NO stable metabolites was revealed in the most examined children-residents of radioactively contami- nated areas by studying NO system after using the course of intermittent normobaric hypoxi therapy. Positive changes in vascular endothelium-dependent reaction to occlusion test, indicating the reduction length of the recovery period for thermographic circulation index after occlusive test, were determined. The decrease in the inten- sity of lipid peroxidation processes – a reduction of serum LPO end products content that react with thiobarbituric acid – was observed. The bronchospasm elimination was revealed in a large number of children with the study of the lung ventilation capacity. There were trends to reduce the imbalance of different chain of the heart rhythm man- agement. The immunomodulatory effect was detected as: the increase in the functional activity of neutrophils, the normalization of humoral immunity link indices. Intermittent normobaric hypoxi therapy is an effective tool that can positively affect the condition of nitric oxide system and endothelium-dependent functions of the organs and systems in children-residents of radioactively contaminated areas.
Key words: children, radioactively contaminated territories, endothelial dysfunction, correction hypoxi therapy.

Problems of radiation medicine and radiobiology. 2016;21:322–335.