Problems of Radiation Medicine and Radiobiology

Ryabchenko N. M., Lypska А. І., Burdo О. О., SovaО. А., Drozd І. P.

Geno- and cytotoxic effects in bone marrow cells and peripheral blood induced by the prolonged administration of 131I to the laboratory rats

Objective: to evaluate the state of to assess the state of hematopoietic system of experimental rats according to the geno- and cytotoxic effects in bone marrow and changes in morphology composition of peripheral blood caused by prolonged 131I intake.
Materials and methods. Within 15 days sodium iodide with activity of 29.3 kBq/animal was daily orally administered to Wistar rats. At 1, 2, 3, 7 and 15 days specific radioisotope activity, level of micronuclei in bone marrow cells, cytotoxicity index, number of erythrocytes and leucocytes in peripheral blood were determined.
Results. It is established that the maximum genotoxic effect induced by 131I prolonged intake was formed at the early terms of observations followed by the reduction of cytogenetic damage in bone marrow cells of rats, while the cytotoxic effect of 131I was formed at the remote terms of administration. Changes in peripheral blood morphology were caused by left shift leukocytosis due to immature forms of neutrophils. In leucograms throughout the experiment increased levels of lymphocyte atypical forms were observed.
Conclusion. Prolonged administration of 131I to the laboratory rats does not cause dose-dependent changes of cyto- and genotoxic markers in the bone marrow and peripheral blood cells.

Key words: 131І, genotoxic effect, cytotoxic effect, bone marrow, hematologic parameters.

Problems of radiation medicine and radiobiology. 2015;20:543-551.