National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"

ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology



Domina E. A.

Anty-radiation means: classification and mechanisms

The objective of the article is to analyze and summarize the literature regarding the mechanisms of action of anti-radiation agents. Depending on their purpose, the modern classification includes radioprotectors, radiomitigators and radio modulators. Attention is drawn to the fact that many traditional radioprotectors, due to the high toxicity, are ineffective under the conditions of prolonged radiological exposure with low dose rate. We look at the purine and organoselenium connections as perspective preventative measures. We study the radioprotective drugs that activate repair systems, based on the model of human peripheral blood lymphocytes and analysis of chromosome aberrations, which are biomarkers of radiation damage to the body. These drugs are recommended to be used for the representatives of certain priority groups of the Ukrainian population that has an increased risk of radiation-induced tumors.

Key words: radioprotectors, inosine, timalin, blood lymphocytes, chromosome aberrations.

Problems of radiation medicine and radiobiology. 2015;20:42-54.

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