National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"

ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology



Mishchuk Y. M., Serga S. V., Koliada O. K., Ostapchenko L. I., Demydov S. V., Kozeretska I. A.

TP53 codon 72 polymorphic variants (Rs1042522) frequency in the Ukrainian population

Objective. To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population.
Materials and methods. We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele-specific polymerase chain reaction.
Results. We identified 31 individuals (20.9 %) with Arg/Arg genotype, Arg/Pro genotype was identified for 116 individuals (78.4 %), whereas genotype Pro/Pro was rare and was found in one person only (0.7 %). Genotype distributions were not within Hardy-Weinberg equilibrium (?2 = 59.7, p < 0.0001).
Conclusions. Arg and Pro allele frequencies in the population of Ukraine are 60 and 40 % respectively, which is significantly differ from the frequencies described in the literature for Poland, the Czech Republic, the USA and Brazil.

Key words: codon 72 polymorphism, gene TP53, the cancer risk, UV radiation.

Problems of radiation medicine and radiobiology. 2015;20:414-419.

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