National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   

 

Dose, and age,dependent cardiovascular mortality among inhabitants of the Chornobyl contaminated areas. 19882010 observation period

V. O. Buzunov1, K. Ye. Prikaschikova1, T. Ye. Domashevska1, G. V. Kostiuk1, I. G. Gubina2,
S. O. Tereschenko2

1State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine
2State Institution Ukrainian Centre of Information Technologies and National Register, Ministry of Health of Ukraine, Kramskogo str. 21, Kyiv, 03115, Ukraine


Objective. The goal of this study was to conduct a descriptive epidemiological analysis of cardiovascular disease mortality among people living in contaminated areas of Ukraine with regard for total cumulative effective doses and age at the time of the Chornobyl accident.
Materials and methods. Depending on respective total cumulative effective doses for 19862010 the people living in contaminated areas of Ukraine were divided into cohorts of those exposed to 5.620.99 mSv (cohort 1) and 21.0050.99 mSv (cohort 2) radiation doses. Each one was stratified by age categories younger than 18 years old, aged 1839 and 4060 respectively. Death rate (ID/103 person-years) and mean error (m) were calculated and Students test (t) was applied to estimate the mortality from cardiovascular diseases for 19882010 period.
Results. The significantly higher (ID/103 person-years is 8.08 0.10) cardiovascular disease mortality was revealed within 19882010 observation period among inhabitants of contaminated areas exposed to 21.0050.00 mSv total effective radiation doses accumulated over 19862010 as compared to that in cohort 1 (ID/103 person-years is 6.29 0.06) for the same period. In the age groups (under 18, 1839 and 4060 years old) exposed to 21.050.0 mSv doses the mortality rate was significantly higher than in the corresponding age groups of the inhabitants with 5.620.99 mSv exposure (1.31 0.08 ID/103 person-years, 8.50 0.19, 48.95 0.33 vs 0.75 0.04, 5.00 0.11, 23.52 0.24 respectively). In the elder age groups with higher radiation doses the mortality was significantly higher (p < 0.05) than in those with lower doses: ID/103 person-years was 1.31 0.08 vs. 0.75 0.04 (those under 18 years); 8.50 0.19 vs. 5.00 0,11 (those aged 1839); 48.95 0.33 vs. 23.54 0.24 (people aged 4060). Among inhabitants with higher radiation doses the mortality rates for certain groups of cardiovascular diseases (coronary heart disease, cerebrovascular disease, arterial hypertension, diseases of arteries, arterioles and capillaries) were sig- nificantly higher compared to those having lower radiation doses.
Conclusions. Cardiovascular mortality among inhabitants of contaminated areas of Ukraine is dependent on the total cumulative effective doses and age at the time of the Chornobyl accident. It is proved by a significantly higher (p < 0.05) mortality in people exposed to 21.0050.0 mSv radiation doses compared to those having 5.620.99 mSv exposures. Mortality was significantly higher (p < 0.05) in age groups with higher doses as opposed to those with low ones. Maximum mortality was observed among inhabitants aged 4060, while the lowest death rate - in patients younger than 18 years old. The data obtained also suggest that the radiation factor can be considered here as one accelerating the aging and pathophysiological abnormalities in survivors. Coronary heart disease, cerebrovascular disease, arterial hypertension, diseases of arteries, arterioles and capillaries are the main causes of death from cardiovascular disease in people under investigation.
Key words: inhabitants, contaminated area, total cumulative effective dose, age, cardiovascular disease, mortality.

Problems of radiation medicine and radiobiology. 2014;19:59-66.


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