National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   

Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress

N. . Rdionova1, N. P. tmaniuk1, L. P. Drevyanko1, V. V. Talko1, A. M. Yanina1,
M. V. Shelkovskiy1, G. V. Kosyakova2, O. Ph. Mehed2, A. G. Berdyshev2, N. M. Gula2,
. . Chumak1
1State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine
2A.V. Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Leontovych str., 9a, Kyiv, 01601, Ukraine

Objective to investigate the peculiarities of peripheral blood indices changes in rats under the N-stearoiletanolamine treatment before and after combined effects of ionizing radiation and stress.
Methods: hematological, statistical.
Results: Per oral administration of NSE (10,0 mg / kg) before and after the combined effects of single whole-body irradiation (6.0 Gy) and emotionally-algesic stress (foot-shock) leads to reduction in the number of circulating peripheral blood cells, increasing signs of damage of the hematopoietic system with accelerated exhaustion processes.
Conclusions. NSE administration (10,0 mg / kg) in rats under the combined influence of ionizing radiation (6 Gy) and emotionally-algesic stress slows down the course of regenerative processes and accelerates the depletion of the hematopoietic system, proving for its radiosensitizing effects.

Key words: rats-male, N-stearoilethanolamine, ionizing radiation, stress, hematological parameters, peripheral blood.

Problems of radiation medicine and radiobiology. 2014;19:441-449.


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