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Late effects of ionizing radiation on functional status of bronchopulmonary system in COPD patients among the clean-up workers of the Chornobyl NPP accident
V. O. Sushko, L. I. Shvaiko, K. D. Bazyka
State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Melnykov str., 53, Kyiv, 04050, Ukraine
The objective of the study was to determine the effects of ionizing radiation on the functional condition of the bronchopulmonary system in clean-up workers of Chornobyl NPP patients with COPD in a remote post-emergency period.
Materials and methods. The study of functional characteristics was carried out in 272 patients – 197 clean-up workers of Chornobyl NPP accident (ChNPPA) with radiation exposure from 25 to 988 mSv; 75 – group of nosological control and 20 healthy persons.
Results and conclusions. For the clean-up workers of Chornobyl NPP with exposure doses over 500 mSv demonstrated correlation between respiratory function parameters and dose which is confirmed for these patients, compared with irradiated in doses less than 500 mSv and nosology control, a significant decreasing of VC (76,3 ± 8,5%, 82,4 ± 8,5% and 82,7 ± 8,1% accordingly, p <0,05), FVC (78,2 ± 8,3%, 84,3 ± 7,9% ³ 86,1 ± 9,7%, p <0,05), FEF 50 (26,1 ± 11,5%, 32,6 ± 10,6% ³ 32,1 ± 12,7%, p <0, 05) ³ FEF 75 (23,8 ± 8,1%, 27,8 ± 9,3% ³ 27,6 ± 9,2%, p <0,05). These changers combined with decrease in lung diffusion capacity in cases more than 500 mSv, and indicate severe respiratory disorders in patients with COPD among clean-up workers of ChNPPA.
Key words: chronic obstructive pulmonary disease, ventilation function of the lungs, ionizing radiation, Chornobyl NPP accident.
Problems of radiation medicine and radiobiology. 2014;19:352-360.
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