National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


ISSN: 2304-8336

Problems of Radiation Medicine and Radiobiology

  
 

   

MULTIPLE MYELOMA AMONG CHORNOBYL ACCIDENT CLEAN-UP WORKERS STATE AND PERSPECTIVES OF ANALYTICAL STUDY

D. A. Bazyka1, N. A. Gudzenko1, I. S. Dyagil1, N. G. Babkina1, V. V. Chumak1, E. V. Bakhanova1, V. V. Paramonov2, A. Ye. Romanenko1
1State Institution National Research Center for Radiation Medicine of the National Academy of MedicalSciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine2Cherkassy Oblast Oncological Clinic

The objective of the study was to analyze the Multiple Myeloma (MM) incidence in clean-up workers preparing the information background for consequent analytical study with a dose-dependent risk estimates.
Materials and methods. The Cohort Database was linked to the Ukrainian National Cancer Registry to identify the MM cases in a cohort of 152 520 male clean-up workers.
Results. The 64 MM cases were identified in the studied Cohort for the 1987-2012 period. Fifty-eight of them were included to the preliminary incidence analysis accounting for the 10-years lag-period. According to the preliminary data analysis the MM incidence rate in studied clean-up workers Cohort did not exceed the corresponding rate in general population of Ukraine along the 21 years after the catastrophe.
Conclusions. Standardized incidence ratio for the 20082012 period, that is 2226 years after the accident, demonstrated the significant excess of MM incidence among male clean-up workers in comparison with general population of Ukraine of corresponding age and gender (SIR 1.61, 95% CI 1.01;2.21).

Key words: Chornobyl accident, clean-up workers, multiple myeloma, incidence.

Problems of radiation medicine and radiobiology. 2013;18:169172.





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