National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   
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DEPENDENCE OF RATS HIGHER NERVOUS ACTIVITY RESPONSE TO STRESS UPON THE DOSE OF PRELIMINARY EXPOSURE TO γ-RADIATION
[Article in Ukrainian]
V. Varetsky1*, O. Rakochi1, M. Shelkovsky1, E. Tukalenko1,2
1State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53, Melnykov str., Kyiv, 04050
2Kyiv Taras Shevchenko National University, Kyiv
*Corresponding author: Viacheslav Varetsky, e-mail: starovyach@ukr.net

Studies of active avoidance behavioral reactions (shuttle and Skinner chambers) changes in totally gamma-exposed and non-exposed rats subjected to stress (foot-shock), showed the following. Indices of conditioned response to stress are generally characterized by direct rise of activity, which later after stressing could be followed by inhibition. Changes of response to the stress in exposed rats nonlinearly depend on the dose of the preliminary exposure: insignificant increase at the dose of .5 Gy, significant increase at 1.0 Gy, insignificant decrease at 3.0 Gy, and significant decrease (to the control level) at 6.0 Gy. Regression analysis showed significant interaction between impact of exposure at the doses of 1.0, 3.0, and 6.0 Gy and non-radiation stress.

Key words: ionizing radiation, stress, rats behavior.

 

Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.365370.





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