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COMPLEX ASSESSMENT OF HEMATOPOIETIC SYSTEM STATE OF LABORATORY ANIMALS UNDER INTERNAL STRONTIUM-90 IRRADIATION
[Article in Ukrainian]
I. Z. Borbulyak1*, N. K. Rodionova2, N. M. Bilko1
1National University “Kyiv-Mohyla Academy”, str. Skovoroda, 2 Kyiv, 04655
2R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Vasylkivska str., 45, Kyiv, 03022
*Corresponding author: Iryna Z. Borbulyak1, e-mail: borbulyak@yahoo.com
Functional activity of the rat hematopoietic system under prolonged exposure to 90Sr was assessed. It was shown using diffusion capsule model that prolonged internal exposure to 90Sr has detrimental effects on hematopoietic stem cells and their progenitors. The most common effects include inhibition of the CFU activity of bone marrow hematopoietic progenitor cells in culture, increase in level of circulating progenitor cells in the peripheral blood. Apart from that, exposure to 90Sr induces inhibition of the CFU activity of stromal bone marrow progenitor cells and inhibition of their hematopoietic stimulatory capacity as feeder layer cells, which are indicative of the hematopoietic micro-environment disturbance.
Key words: hematopoietic progenitor cells, in vitro and in vivo cell culture, hematopoietic microenvironment, internal chronic radiation exposure, Strontium-90.
Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.359–364.
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