National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   
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THE DISTRIBUTION OF rs966221 PDE4D GENES GENOTYPES IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS DEPENDING ON RADIATION ANAMNESIS
[Article in Ukrainian]

. . Chumak, N. I. Bilous, G. V. Pleskach, Z. V. Martina, I. S. Dyagil, I. V. Abramenko*
State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: Iryna V. Abramenko, e-mail: nbilous@yahoo.com

The rs966221 PDE4D genes polymorphism was studied in 123 chronic lymphocytic leukemia (CLL) patients and 242 controls. The lower frequency of CC genotype was revealed in ionizing radiation (IR) non-exposed CLL patients (26%; =0.041) comparing with IR-exposed CLL patients (43.4%) and controls (38.4%; p=0.06). The association of CC genotype with unmutated variable heavy chain genes (UM IGHV) and lower frequency of UM IGHV1 gene family in IR-exposed CLL patients was found. The assumption about some peculiarities of leukemic CLL clone formation in carriers of different rs966221 genotypes under IR influence was proposed.

Key words: Chornobyl NPP accident, chronic lymphocytic leukemia, ionizing radiation, rs966221 PDE4D genes polymorphism.

 

Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.334341.





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