National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   
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THE FREQUENCY ANALYSIS OF THE MOST COMMON MUTATIONS IN GENES BRCA1 AND BRCA2 IN WOMEN, WHICH TOOK PART IN THE LIQUIDATION OF CHORNOBYL DISASTER CONSEQUENCES
[Article in Ukrainian]
L. A. Rybchenko, A. M. Bychkova, G. V. Skyban, N. E. Yaroshenko, S. V. Klymenko*
State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: SergiiV. Klymenko, e-mail: klymenko_sergiy@yahoo.co.uk

The frequency of mutations in genes BRCA1 and BRCA2 was investigated among women-liquidators of Chornobyl disaster consequences; the 5382insC mutation of the BRCA1 gene is dominant among the studied spectrum of mutations (its frequency is 5.9% in the group of women with breast cancer (BC) and 1.1% in the group of women without BC.

Key words: breast cancer, mutations, BRCA1 and BRCA2 genes, DNA-analysis, clinical and genealogical research, Chornobyl disaster.

 

Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.267273.





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