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INCIDENCE OF NON-CANCER ENDOCRINE DISEASE
IN ChNPP ACCIDENT SURVIVORS
(comparative analysis of clinical data to the entire population)
[Article in Ukrainian]
O. V. Kaminskyi, O. M. Kovalenko
State Institution “National Research Center for Radiation Medicine, National Academy of Medical Sciences of Ukraine” Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: Oleksii V. Kaminskyi, e-mail: endocrin@voliacable.com
The study was held among 606 survivors of the ChNPP accident including the clean-up workers and evacuated persons, and 589 subjects representing the general population of Ukraine. Received data indicate to the incidence increase of endocrine disease namely diffuse non-toxic goiter, nodular goiter, type II diabetes mellitus, pre-obesity, and obesity in ChNPP accident emergency workers of the so-called “iodine” period vs. general population. There is a dependence of serum thyrotropin content, titer of autoantibody to thyroglobulin and insulin resistance markers on the external radiation dose values. The non-cancer hypertrophic, hyperplastic and autoimmune processes defining the onset of diffuse non-toxic goiter, nodular goiter, and chronic autoimmune thyroiditis are prevalent in ChNPP accident emergency workers and evacuees vs. the thyroid disease in general population.
Key words: ChNPP accident, clean-up workers, ionizing radiation, endocrine system, thyroid gland.
Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.176–182.
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