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Problems of Radiation Medicine and Radiobiology

  
 

   
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CLINICAL PECULIARITIES OF CHRONIC LYMPHOCYTIC LEUKEMIA DEPEND ON rs966221 PDE4D GENES GENOTYPES
[Article in Ukrainian]
I. S. Dyagil, Z. V. Martina, N. I. Bilous, G. V. Pleskach, I. V. Abramenko*, . . Chumak
State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: Iryna V. Abramenko, e-mail: nbilous@yahoo.com

Clinical course of chronic lymphocytic leukemia (CLL) depend on rs966221 PDE4D genes polymorphism and mutational status of variable heavy chain genes (IGHV) was studied in 126 patients. It was found that genotype TT was associated with lower effectiveness of second line therapy (p=0.03), more frequent development of autoimmune anemia (p=0.09), expecially in unmutated IGHV genes (p=0.012) and more frequent development of cytopenias after chemotherapy (p=0.073). But, the differences in CLL course in carrieis of CC genotype, the frequency of which differed depend on radiation anamnesis of patients, were not revealed.

Key words: Chornobyl NPP accident, chronic lymphocytic leukemia, ionizing radiation, rs966221 PDE4D genes polymorphism.

 

Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.155162.





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