National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   
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INFLUENCE OF CORTISOL AND THYROID GLAND HORMONES ON A CONDITION OF BONE STRUCTURES IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIAS
[Article in Ukrainian]
V. G. Bebeshko, K. M. Bruslova*, N. M. Tsvetkova, V. I. Kolos, E. E. Kuznetsova,
L. O. Gonchar, T. I. Belingio, T. I. Puchkariova, L. P. Mishchenko,
O. V. Lishchenko, I. V. Trihleb

State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine
*Corresponding author: Kateryna M. Bruslova, -mail: dr.bruslova@mail.ru

At 30,4 % of patients with acute lymphoblastic leukaemias (ALL) changes of levels cortisol and thyroid gland hormones that was combined with shorter life expectancy are observed. The maintenance osteocalcine in the blood of patients in 1,7 times more low in comparison with healthy children. In the debut of period ALL in children to light deficiency of calcium and increase alkaline phosphatase in blood. It is established a disbalance of aminoacids which are a part structure of collagen of bones, increase phosphates of calcium and decrease in density of bones. Results of researches can lay down in a basis of updating of program therapy ALL in children.

Key words: acute lymphoblastic leukaemia, children, cortison, thyroid gland, structure of bones.

 

Probl. Radiac. Med. Radiobiol. 2012. Issue 17. P.117126.





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