National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   
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QUANTITATIVE PECULIARITIES OF THE CONTENTS OF PROSTAGLANDINS AND THEIR METABOLITES IN THE SPERM OF MEN INHABITING IN DIFFERENT REGIONS OF UKRAINE
[Article in Ukrainian]
Yu. A. Kondratova, A. V. Klepko, S. V. Andreychenko
SI National Research Center for Radiation Medicine, Academy of Medical Sciences of Ukraine, Kyiv

The sperm concentration of E and F-prostaglandins along with their physiologically active metabolites 19-OH PGE and 19-OH PGF were determined by the aid of gaschromatography in association with mass-spectrometry in the ejaculates samples from men-volunteers inhabiting 4 regions of Ukraine with different levels of terrestrial radiation pollution. According to the spermogram data analysis the spermodonors from Zhytomyr region have shown an obvious tendency for oligozoospermy and astenozoospermy as well as diminishing of ejaculate volume. In inhabitants of Kyiv and Kyivs region such a tendency significantly decreased while in donors from Ivano-Frankivsk and Poltava regions it was not observed at all. The average concentration of E-prostaglandins in the sperm was defined to increase gradually in the group rank from Zhytomyr to Poltava region, whereas the mean value of concentration for F-prostaglandins. Simultaneously the statistically valid raise of 19-OH PGE contents and the corresponding abatement of 19-OH PGF concentration in sperm fluid was found of men originating from Poltava and Ivano-Frankivsk regions when compared to the Kyiv, Kyivs and Zhytomyr regions.

Key words: prostaglandins, human sperm, semen plasma, motility, irradiation, radioactive polution.

 

Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P. 365371.





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