National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology

  
 

   
< back

IONIZING RADIATION INFLUENCE ON MORPHOFUNCTIONAL STATE OF PITUITARY-GONADAL SYSTEM OF FEMALES RATS
[Article in Ukrainian]
L. P. Derevianko1, V. V. Talko1, N. P. Atamaniuk1, O. G. Chernenko2, A. M. Yanina1,
N. V. Didenko1, N. K. Rodionova1

1SI National Research Center for Radiation Medicine National Academy of Medical Sciences of Ukraine, Kyiv
2The State Institution Institute of Neurosurgery named by acad. A. Romodanov National Academy of Medical Sciences of Ukraine, Kyiv

Studies of ionizing radiation influence in doses 2.0 and 6.0 Gy on morphofunctional state of pituitary-gonadal system of matured females rats were conducted in dynamics (7, 14, 30 days). Morphofunctional changes in hormonproducing ovary and adenopituitary cells after total single irradiation of females rats in doses 2.0 and 6.0 Gy in remote period of observation (90 days) were found. Influence of ionizing radiation on ovaries showed itself to be doses dependent indecrease of the primary follicules quantity, in early degenerative changes of sex syncitium, in follicules ripening kinetics of different stages changes. Simultaneously with proliferation processes intensification apoptosis and distrophic epithelium changes were stirred up. These changes were found in the places of disturbed microcirculatory blood flow. Obtained results evidence changes in pituitary-gonadal system of animals in the described conditions of irradiation, wheach lead to disturbances of hormonal regulation.

Key words: ionizing radiation, females rats, adenopituitary, ovaries.

 

Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P.277283.





full text
Home | Editorial board | For Authors | Archive | Search
© 2013 Problems of Radiation Medicine