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State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   
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IMPACT OF MEASUREMENT ERRORS IN THYROID DOSES ON DOSE-RESPONSE ANALYSIS

[Article in Ukrainian]
S. V. Masiuk1, S. V. Shklyar2, A. G. Kukush2

1SI National Research Center for Radiation Medicine, National Academy of Medical Sciences of Ukraine", Kyiv
2National Taras Shevchenko University of Kyiv

In paper, impact of classic measuring errors in the thyroid doses on the dose-response analysis is researched by a method of stochastic imitation. It is show that the presence of errors in doses results in bias of the naive estimations of baseline morbidity and excess absolute risk in the linear logistic model of regression. With the increase of dose errors, displacements of naive estimations increase nonlinear. The use of the non-naive methods of evaluation developed by authors substantially improves the estimations of parameters of the excess absolute risk model.

Key words: doses of exposure, radiation risk, classical measurement error, full maximum likelihood estimating procedure, regression calibration, naive estimation.

 

Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P. 2529.





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