National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


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Problems of Radiation Medicine and Radiobiology

  
 

   
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EFFECTS OF PRECEDING γ-IRRADIATION AT LOW DOSES UPON RATS HIGHER NERVOUS ACTIVITY RESPONSE TO STRESS
[Article in Ukrainian]
V. Varetsky1, O. Rakochy1, M. Shelkovsky, E. Tukalenko1,2, I. Dmitrieva1, V. Pakholchenko1,2
1SI National Research Center for Radiation Medicine of NAMS of Ukraine, Kyiv
1Kyiv Taras Shevchenko National University, Kyiv

Studies of active avoidance behavioral reactions (shuttle box) changes under exposure to stress (foot-shock) in the rats preliminary exposed to single total γ-radiation at doses of 0.5 and 1.0 Gy gave the following results. Reactions of conditioned behavior indices to stress are individual, but in general they are characterized by significant direct effect of activation, which could be followed by depression during time period after stress application. Effects of stress in the rats previously exposed at the dose of 1.0 Gy exceed those in the animals both directly after stress application and during the time periods without stress. Interaction between factors of ionizing radiation and stress were found for the tested indices at the dose of 1.0 Gy. In the rats exposed at the dose of 0.5 Gy increase of direct response to stressing was not found, but it was evident in delayed responses.

Key words: ionizing radiation, stress, rats behavior.

 

Probl. Radiac. Med. Radiobiol. 2011. Issue 16. P. 120125.





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