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I. S. Dyagil, I. V. Abramenko, Z. V. Martina, N.A. Golyarnic, V. V. Brychenko, A. V. Movchan,
A. A. Chumak, D. A. Bazyka
State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine
THE COURSE OF CHRONIC LYMPHOCYTIC LEUKEMIA AFTER SARS-COV-2 VIRUS INFECTION
Objective – to investigate the course of B-cell chronic lymphocytic leukemia (CLL) in patients after SARS-CoV-2
virus infection taking into account anamnestic exposure to the ionizing radiation (IR).
Methods. The study was performed in a group of 51 CLL patients who were admitted to the Department of Radiation
hematology of the National Research Center for Radiation Medicine of NAMS of Ukraine, Kyiv, from January 2020 (the
beginning of SARS-CoV-2 epidemic) to August 2023. The group included 19 (37.3 %) clean-up workers of the
Chornobyl NPP accident, 15 (29.4 %) inhabitants of radionuclide contaminated areas and 17 (33.3 %) IR nonexposed patients. The diagnosis of CLL was based on clinical history, lymphocyte morphology, and immunophenotypic criteria. Statistical studies were performed using the SPSS software package, version 20.0.
Results. The diagnosis of CLL was established for the first time in 14 patients, in seven of them, CLL was diagnosed
after 2–17 months after SARS-CoV-2 infection. In contrast to patients who did not suffer from a coronavirus infection, they had pronounced lymphadenopathy, which in some cases was accompanied by hyperleukocytosis, and
needed early treatment. Thirteen patients with a previously established CLL were diagnosed with COVID-19 by PCR
test. In seven of them (53.8 %) starting treatment was needed, or CLL has progressed. Seven of 51 patients (13.5 %)
were vaccinated against SARS-CoV-2. Then, four of them were diagnosed with SARS-CoV-2 infection, confirmed by a
positive PCR test, and two patients had a relapse of CLL within 1-2 months after vaccination. Most of patients with
signs of the influence of SARS-CoV-2 infection on CLL belonged to sufferers of the Chornobyl NPP accident
Conclusions. The clinical features of CLL that developed after SARS-CoV-2 were characterized firstly. The negative
impact of SARS-CoV-2 infection on previously established CLL was established. The question about vaccination of
CLL patients remains debatable.
Key words: chronic lymphocytic leukemia, SARS-CoV-2, Chornobyl NPP accident.
Problems of Radiation Medicine and Radiobiology.
2023;28:267-276. doi: 10.33145/2304-8336-2023-28-267-276
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